Ketoprofen USP 12gm

NDC #: 69746-0100-82


Ketoprofen serves as a versatile analgesic and antiinflammatory agent that’s effective whether delivered orally or topically. A meta-analysis of randomized controlled trials found that orally administered Ketoprofen relieved moderate-to-severe pain and improved functional status significantly better than ibuprofen. 1 Topical Ketoprofen reliably alleviates pain arising from acute musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. 2

Pharmaceutica North America provides high-quality Ketoprofen in the form of bulk and unit-dose active pharmaceutical ingredients. As one of the nation’s leading compounding pharmaceutical companies, we’re proud to guarantee rapid delivery of stable products that are manufactured and distributed in accordance with cGMP at an FDA- and DEA-registered facility.

Approved and Potential Uses of Ketoprofen:

Ever since its approval in 1986, Ketoprofen has been widely used for its analgesic, antipyretic and anti-inflammatory activities. It belongs to the propionic derivative class of NSAIDs, which are cyclooxygenase 1 and 2 (COX-1 and COX-2) inhibitors that block prostaglandin formation. It may also reduce inflammation by decreasing proinflammatory cytokine activity and inhibiting neutrophil aggregation or chemotaxis.

Consider using it for the following conditions:

  • Osteoarthritis – Oral and topical NSAIDs such as Ketoprofen are recommended for hand and knee osteoarthritis; elderly patients should use topical applications to avoid potential systemic adverse effects.
  • Rheumatoid arthritis – Oral delivery to reduce swelling and pain; topical application for acute pain.
  • Dysmenorrhea – Treats cramping pelvic pain due to primary and secondary dysmenorrhea.
  • Muscle pain, sprains and strains – Oral and topical delivery are effective; Topical 2.5 percent Ketoprofen Gel was superior to placebo for alleviating pain due to ankle sprain in the emergency department. 3
  • Orofacial pain – To relieve postoperative dental pain, temporomandibular joint disorder and toothache.
  • Pain management – General mild-to-moderate pain from diverse causes.

Off-label use:

  • Vascular headache – Oral Ketoprofen is beneficial in some patients with vascular and episodic tension-type headaches. While still investigational, a Topical Ketoprofen Gel to treat migraine headaches has passed Phase Ib and IIa clinical trials.

When you purchase Ketoprofen from Pharmaceutica North America, you gain competitive pricing along with personal attention and a team with years of expertise in navigating the pharmaceutical supply chain. Contact us today to learn about our fast shipping and to experience first-class customer service in action.

Show 3 footnotes

  1. “Efficacy of Ketoprofen vs. Ibuprofen and Diclofenac: A Systematic Review of the Literature and Meta-Analysis,” September 2013,
  2. “Topical NSAIDs for Acute Musculoskeletal Pain in Adults,” June 2015,
  3. “Topical Ketoprofen Versus Placebo in Treatment of Acute Ankle Sprain in the Emergency Department,” September 2016,