API: Ketoprofen

What Is Ketoprofen and How Does It Work?

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory, antipyretic and analgesic properties. The drug works by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly. COX enzymes are associated with the production of prostaglandins at the injury site, which cause both pain and inflammation. Blocking COX enzymes decreases prostaglandin production, thereby lowering pain and inflammation. Ketoprofen is used to treat mild to moderate pain of many different causes.1

For more information, including a MSDS sheet, please see PNA’s Ketoprofen page.

Approved Indications2

  • Arthritis: Ketoprofen is used to treat pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints).
  • Menstrual pain: Ketoprofen is used to treat pain and tenderness due to premenstrual cramps and dysmenorrhea.
  • Other conditions: Ketoprofen can also relieve mild to moderate pain due to headaches, toothaches, muscle aches, backaches, and cold symptoms, and may also reduce fever.

Side Effects and Drug Interactions

Common side effects in patients taking ketoprofen include3:

  • Acid or sour stomach
  • Bloating or gas
  • Vivid dreams
  • Full feeling
  • General feeling of discomfort or illness
  • Irritability, excitability, and other mood changes
  • Lack of appetite
  • Loss of interest or pleasure
  • Sleepiness and fatigue
  • Insomnia
  • Trouble concentrating

Patients who suffer from severity of these common side effects should contact their pharmacist or physician right away. Patients who experience abdominal pain, cloudy or bloody urine, decreased frequency or amount of urine, pain or burning when urinating, headache, increased blood pressure, lower back or side pain, nausea, rash or swelling of face, fingers, feet, or lower legs, trouble breathing, extreme fatigue, vomiting or weight gain should inform their physician immediately.

Patients who are allergic to ketoprofen should not take this drug. Patients who are allergic to other NSAIDs should speak to their pharmacist or physician before starting this medication.4

Some products that may interact with this drug include: aliskiren, ACE inhibitors, angiotensin II receptor blockers, methotrexate, probenecid, corticosteroids, and medications that may affect the kidneys (such as cidofovir, cyclosporine, tenofovir, and diuretic pills). This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding, such as anti-platelet drugs and blood-thinners. This drug can also slow the removal of other medications, such as lithium, from the body.

Latest News and Research

Ketoprofen was first developed in 1986 in the U.S. and is still widely used today. A systematic review of the use of ketoprofen against the activity of both ibuprofen and diclofenac shows that ketoprofen offers better relief of moderate to severe pain and overall improvement in terms of overall condition and body function.5

Research into new uses for the drug continue. For example, ketoprofen is currently not indicated for use as an analgesic for post-surgical pain. However some studies indicate that ketoprofen is effective for managing short term postoperative pain, such as for abdominal surgery when delivered intravenously.6 Results may even be improved if the drug is delivered in conjunction with acetaminophen.7

Ketoprofen also shows promise for transdermal delivery against delayed onset of muscle soreness in athletes.8

Buying Guide

PNA is a recommended bulk supplier of Ketoprofen and other APIs. You can learn more about Ketoprofen here.

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Show 8 footnotes

  1. “Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronic conjugates of ketoprofen,” November 15, 2004, http://www.ncbi.nlm.nih.gov/pubmed/15476667
  2. “Ketoprofen,” July 9, 2015, https://www.nlm.nih.gov/medlineplus/druginfo/meds/a686014.html
  3. “Ketoprofen Side Effects,” December 1, 2015, http://www.drugs.com/sfx/ketoprofen-side-effects.html
  4. “ketoprofen – oral, Orudis,” http://www.medicinenet.com/ketoprofen-oral/page5.htm#DrugInteractions
  5. “Efficacy of ketoprofen vs. ibuprofen and diclofenac: a systematic review of the literature and meta-analysis,” 2013, http://europepmc.org/abstract/med/23711416
  6. “Intravenous ketoprofen in postoperative pain treatment after major abdominal surgery, 2005, http://www.ncbi.nlm.nih.gov/pubmed/15776297
  7. “Combining Paracetamol (Acetaminophen) with Nonsteroidal Antiinflammatory Drugs: A Qualitative Systematic Review of Analgesic Efficacy for Acute Postoperative Pain,” April 2010, http://journals.lww.com/anesthesia-analgesia/Abstract/2010/04000/Combining_Paracetamol__Acetaminophen__with.30.aspx
  8. “Efficacy of Transdermal Ketoprofen for Delayed Onset Muscle Soreness,” July 2003, http://journals.lww.com/cjsportsmed/Abstract/2003/07000/Efficacy_of_Transdermal_Ketoprofen_for_Delayed.2.aspx